COX-2-specific inhibitors have, largely, been removed from the market for increasing risk of heart attack and stroke (3). NSAIDs, for instance, work by inhibiting both COX-1 and COX-2. COX-1 usefully maintains the normal lining of the stomach and intestines, and is involved in kidney and platelet function COX-2, however, is primarily found at sites of inflammation. To break that down: COX stands for cyclooxygenase, an enzyme that forms compounds responsible for the inflammatory response (3). It “prevents inflammation by inhibition of the COX pathway, decreasing NF-kB translocation, and suppressing TNF-a as well as IL-5 and IL-13 mRNA expression.” The oil contains thymoquinone, a compound that “occupies vital significance” in the anti-inflammatory pathway, according to the authors. Top among them: anti-inflammatory effects. Oil extracted from these seeds has been used in traditional medicine for over 2,000 years.īlack seed oil is considered to have a variety of properties that may benefit health, neatly summarized in Health-Promoting Activities of Nigella sativa Fixed Oil (2). It produces fruit with black seeds-which, while they go by the name “black seeds,” are also called black cumin, black caraway, nigella, fennel flower, and Roman coriander (1). Nigella sativa grows in Southwest Asia, the Middle East, and Southern Europe.
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